The Active Ingredient In Glucophage Xr Is Metformin Hydrochloride (750 Mg), Which Works By Reducing Glucose Production In The Liver, Improving Insulin Sensitivity, And Enhancing Glucose Utilization By Cells. Side Effects Of Glucophage Xr 750 Mg Tablet Gastrointestinal Issues: Nausea, Vomiting, Diarrhea, Stomach Pain, Or Flatulence. Metallic Taste: A Slight Metallic Taste In The Mouth. Vitamin B12 Deficiency: Long-Term Use Can Reduce B12 Absorption, Causing Fatigue Or Neuropathy. Lactic Acidosis (Rare But Serious): Symptoms Include Muscle Pain, Difficulty Breathing, And Fatigue. Hypoglycemia: Rare, But Possible When Combined With Other Diabetes Medications. Skin Reactions: Rash, Itching, Or Redness. If These Side Effects Persist, Consult A Healthcare Provider.