Product description Zestoretic 10 mg/12.5 mg and 20 mg/12.5 mg tablets Lisinopril, hydrochlorothiazide Zestoretic is used to treat high blood pressure (hypertension). It contains two medicines called lisinopril and hydrochlorothiazide. Lisinopril belongs to a group of medicines called ace inhibitors. It works by making your blood vessels widen. Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets). It helps your body to get rid of water and salts like sodium in your urine. These medicines work together to lower your blood pressure. Taking your medicine Swallow the tablet with a drink of water. Try to take your tablets at the same time each day. It does not matter if you take zestoretic before or after food. Keep taking zestoretic for as long as your doctor tells you to, it is a long-term treatment. It is important to keep taking zestoretic every day. Taking your first dose Take special care when you have your first dose of zestoretic or if your dose is increased. It may cause a greater fall in blood pressure than later doses. This may make you feel dizzy or light-headed. If this happens, it may help to lie down. If you are concerned, please talk to your doctor as soon as possible. Adults The recommended dose is one tablet once a day. Your doctor will prescribe the tablet that is the right strength for you. If necessary, your doctor may increase your dose to two tablets once a day. Use in children Zestoretic is not recommended for use in children. Possible side effects with lisinopril Severe allergic reactions, severe liver problems, headache, feeling dizzy or light-headed, especially if you stand up quickly, fainting, diarrhoea, being sick (vomiting), cough