Actos Is An Oral Medication Containing Pioglitazone, Which Works By Increasing The Body'S Sensitivity To Insulin And Regulating Blood Sugar Levels. Pioglitazone (As Pioglitazone Hydrochloride) – 15 Mg Common Side Effects: Edema (Swelling) Weight Gain Headache Muscle Pain Increased Risk Of Bone Fractures Bladder Cancer (In Rare Cases) Hypoglycemia (If Taken With Other Diabetes Medications) Liver Problems (Rare)