CIVAR Cream is a prescription medicine used to treat the symptoms of cold sores (Herpes Labialis) andGenital Herpes, cream may be used alone or with other medications. CIVAR Cream belongs to a class of drugs called Antivirals. What is topical acyclovir used for? Topical acyclovir is applied to the skin and is commonly used to treat certain symptoms associated with cold sores and genital herpes. Topical acyclovir may also be used for other conditions as determined by your healthcare provider. How is it used? cream is applied to the skin