Co Approvel 150/12.5mg is a combination medication containing irbesartan and hydrochlorothiazide used to treat high blood pressure. Each pack contains 28 film-coated tablets manufactured by Sanofi Aventis. The tablets combine an angiotensin II receptor blocker with a diuretic for effective blood pressure control. Each film-coated tablet contains 150mg of irbesartan and 12.5mg of hydrochlorothiazide. The medication works through two mechanisms - irbesartan blocks the action of angiotensin II which causes blood vessels to narrow, while hydrochlorothiazide helps remove excess fluid from the body. This combination helps lower blood pressure more effectively than either component alone. The tablets should be taken once daily as prescribed by your healthcare provider. This is a prescription-only medication that requires regular monitoring by a physician.