Diflucan is a prescription antifungal medication containing 150mg of fluconazole per capsule. This single-dose treatment comes in a box containing one capsule and is manufactured by Pfizer. It is used to treat various fungal infections and requires a valid prescription for purchase. Diflucan (fluconazole) is an antifungal medication used to treat various fungal infections including vaginal yeast infections, oral thrush, and certain systemic fungal infections. The 150mg single capsule format is typically used as a one-time dose for vaginal yeast infections. This medication works by stopping the growth of certain types of fungi. As with all prescription medications, it should only be taken under medical supervision and after consultation with a healthcare provider. Side effects and contraindications should be discussed with your doctor before use.