Janumet XR 100/1000mg is a prescription medication that combines sitagliptin and metformin in an extended-release formulation. This combination medication is used to help control blood sugar levels in patients with type 2 diabetes. Each bottle contains 28 coated tablets. The medication contains two active ingredients: sitagliptin (100mg) and metformin (1000mg) in an extended-release (XR) formulation. The tablets are taken orally as prescribed by a healthcare provider. This product is manufactured by MSD (Merck Sharp & Dohme).