Toplexil 0.33mg/ml syrup 150ml

This medicine is a combination of substances which contains an antihistamine, antitussive and sedative (Oxomemazine), two expectorants (Guaifenesin and Sodium benzoate) and antipyretics (paracetamol). Guaifenesin is absorbed from the gastrointestinal tract it is melabolised and then excreted in the urine. Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses and is distributed into most body tissues. It crosses the placenta and is present in breast milk. Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol. Sodium benzoate is absorbed from the gastrointestinal tract and conjugated with glycine in the liver to form hippuric acid, which is rapidly excreted in the urine. Indications: It is used in the treatment of dry and wet cough, including allergies and irritants. Dosage and administration: Treatment should not exceed a few days. The use of this medication must be distributed during the day. Adults: – 1 or 2 teaspoons of syrup, 2 or 3 times a day. In the elderly, starting with the lowest dose. – Don’t use this medicine for children under 6 years without medical advice. Children: – Above 30 months: 3 to 5 teaspoons of syrup per day, in 2 or 3 divided doses under medical advice – From 24 to 30 months: 1 to 3 teaspoons of syrup per day, in 2 or 3 divided doses under medical advice – Don’t use this medicine for children under 2 years.